Kacef MC

Kacef MC

Cephalexin + Kanamycin

Intramammary Ointment (Dry Period Use)

Pharmacological Group:

Antibiotic

Dosage Form:

Intramammary Ointment

Composition:

Each 8-gram syringe contains:

• Cephalexin Monohydrate – 200 mg
• Kanamycin Monosulfate – 100,000 IU

Mechanism of Action:

This product is a combination of Cephalexin and Kanamycin in a 1.5:1 ratio.

• Cephalexin is a first-generation cephalosporin antibiotic in the β-lactam class, exerting time-dependent antibacterial activity mainly against Gram-positive bacteria by inhibiting peptidoglycan synthesis in bacterial cell walls.
• Kanamycin is an aminoglycoside antibiotic with concentration-dependent activity, inhibiting bacterial protein synthesis by interfering with accurate translation at the ribosomal level. It is effective against Gram-negative pathogens and Staphylococcus aureus.

The combination of Cephalexin and Kanamycin provides a bactericidal effect against both Gram-positive and Gram-negative bacteria, and is more effective than either agent alone in controlling the bacterial pathogens responsible for clinical mastitis.

Indications:

Treatment of clinical mastitis in lactating cows, caused by pathogens sensitive to the Cephalexin-Kanamycin combination, including:

• Staphylococcus aureus
• Streptococcus agalactiae
• Streptococcus dysgalactiae
• Streptococcus uberis
• Escherichia coli
• Coagulase-negative Staphylococci

Dosage and Administration:

• Route: Intramammary
• Dosage: One full syringe (200 mg Cephalexin + 100,000 IU Kanamycin) per affected quarter
• Frequency: Administer twice, 24 hours apart
• Each syringe is for single use only

Administration Instructions:

• Fully drain the milk from the udder before treatment
• Clean and disinfect the teat thoroughly
• Ensure the injection tip remains sterile during administration

Contraindications:

• Do not use in cows with known hypersensitivity to Cephalexin or Kanamycin
• Not for use in dry cows
• Do not use in cases where antibiotic resistance to the components is known

Precautions:

• Studies indicate no teratogenic effects, so the product may be used in pregnant cows

Drug Interactions:

• Resistance to Cephalexin may indicate cross-resistance to other cephalosporins
• Resistance to Kanamycin may imply cross-resistance to neomycin and paromomycin

Withdrawal Periods:

• Meat: 10 days
• Milk: 5 days

Storage Conditions:

Store in a dry place at a temperature below 30°C