MetriCeph

MetriCeph

(Intrauterine Antibiotic Syringe)

Composition:

Each syringe contains:

• Cefquinome sulfate – 900 mg

Pharmaceutical Group:

• Fourth-generation cephalosporin antibiotic (β-lactam class)

Mechanism of Action:

Cefquinome is a fourth-generation cephalosporin that inhibits bacterial cell wall synthesis by blocking peptidoglycan cross-linking, leading to bacterial cell lysis and death (bactericidal effect). It is highly resistant to β-lactamase enzymes, making it effective in the uterine environment where resistant pathogens may be present.

Cefquinome demonstrates broad-spectrum antimicrobial activity against both Gram-positive and Gram-negativebacteria, including key pathogens involved in bovine uterine infections:

• Actinomyces spp.
• Corynebacterium pyogenes
• Anaerobes such as Fusobacterium spp.

Indications:

For the treatment of uterine infections in cattle, including:

• Clinical and subclinical endometritis
• Metritis
• Retained placenta
• Post-dystocia infections

Administration and Dosage:

• Intrauterine use only
• Administer one syringe per cow as a single dose
• If necessary, a second dose may be administered after 72 hours

Instructions for administration:

1. Attach the syringe to a sterile intrauterine catheter.
2. Using a sterile rectal glove, perform a rectal examination to guide the catheter through the cervix and into the uterine body.
3. Inject the full contents of the syringe into the uterus.

Packaging:

• Box of 10 syringes
• Each box includes:
  • 10 sterile intrauterine catheters
  • 10 sterile obstetric (rectal) gloves

Withdrawal Periods:

• Milk: 2 days
• Meat: 5 days

Contraindications and Precautions:

• Do not use in pregnant animals
• Contraindicated in animals with a known hypersensitivity to cephalosporins or penicillins
• Do not co-administer with other intrauterine treatments
• Avoid contact with skin and mucous membranes; gloves must be worn during administration

For Veterinary Use Only